Trailer: Splice

In a medical research lab buried under Chicago, two scientists seek to continue the groundbreaking research of Dr. Susan McCallister whose life was tragically cut short when she was eaten by a super-intelligent shark.  Their search for a cure for Alzheimer's leads them into stem-cell research which leads them into human cloning.  The cloning rabbit hole (so cleverly referenced by the underground lab) of course leads to genetic experimentation, because let's face it, what else are you gonna do in your underground science lab?  I mean, if you're not turning people invisible, your splicing human and pokemon DNA.

Everything's going great for the doctors Moreau until their female-ish creation undergoes a sexual awakening and channels the plot of Species.  It's all downhill after that as the woman-thing comes on to her "daddy" and then enters a shame spiral of self-destructive behaviours.  While searching for meaning in a meaningless story, our heroes are constantly dogged by government spooks who want to at once bury the experiment and use the scientific breakthrough to create a new breed of soldier.

Keep an eye out for the in-name-only sequel in which a scientist mutates into a giant man-fly.